METHOD FOR THE EVOLUTIONARY DESIGN OF BIOCHEMICAL REACTION NETWORKS

摘要

The present invention relates to methods for achieving an optimal function ofa biochemical reaction network. The methods can be performed in silico using areconstruction of a biochemical reaction network of a cell an iterativeoptimization procedures. The methods can further include laboratory culturingsteps to confirm and possibly expand the determinations made using the insilico methods, and to produce a cultured cell, or population of cells, withoptimal functions. The current invention includes computer systems andcomputer products including computer-readable program code for performing thein silico steps of the invention.