METABOTROPIC GLUTAMATE RECEPTOR 7(MGLUR7)-BINDING ANTIBODY

摘要

The present invention provides an antibody directed to an epitope of a G -protein coupledreceptor, wherein the antibody binds to the extracellular N terminal region ofthe receptor andthe binding of the antibody to the G - protein coupled receptor inducesreceptor internalization incells, wherein the receptor is metabotropic glutamate receptor 7 (mGluR7) andwherein theantibody is produced by hybridoma cell line deposited with DSMZ as DSMACC2855.