USE OF GIP FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH DYSFUNCTIONAL SYNAPTIC TRANSMISSION

摘要

The present invention relates to a peptide comprising at least 12 amino acidresidues from the N-terminal end of gas-tricinhibitory polypeptide, or an analogue thereof, which are useful toprophylactically prevent, improve, or reverse the diminishedcognitive function associated with these types of disorders, by increasing (orsustaining) the LTP of synaptic transmission. Moreover,sustaining LTP may find utility in the prophylaxis of neurological disease bydelaying the onset of impaired cognitive processes, andcould serve as a treatment, not only for the diminished cognitive functioncaused by neurodegeneration, but also for the dysfunctionalcognitive processes associated with trauma or age. Additionally, the peptidesand analogues of the present invention find are usefulto improve the altered cognitive function associated with hyperexcitability-type disorders, by reducing the elevated level of LTP ofsynaptic transmission.