The invention relatesto immunoassays, reagents,therapeutics and methods of diagnosing andprognosis evaluation of idiopathicmembranous nephropathy (MN).Immunoassays comprise enzyme-linkedimmunoabsorbent assays andnephelometric immunoassays for serumauto-antibodies reactive against aphospholipase A2 receptor (PLA2R).Therapeutic methods include removalof the auto-antibodies by adsorbanceor administration of soluble PLA2Ror fragments to sequester theauto-antibodies.
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