TRANSLOCATION INTERFERING TOLL-LIKE RECEPTOR 3(TLR3) VARIANTS FOR SUPPRESSING TOLL-LIKE RECEPTOR ACTIVITY AND USES THEREOF

摘要

Agents interfering with translocation of Toll-likereceptor 3 (TLR3), wherein the agents are TLR3 variants,methods of making these agents, and use of the foregoing forsuppressing TLR3 activity are disclosed. Described uses includetreating or preventing inflammatory conditions, necroticconditions, infectious diseases, type I or type II diabetes,cancers, rheumatoid diseases, pulmonary diseases andneurological disorders.