METHOD AND MULTI-SENSOR DEVICE FOR NONINVASIVE MONITORING OF BLOOD GLUCOSE LEVELS

摘要

The inventions relate to medicine and medical technology, and particularly to the monitoring of blood glucose levels by measuring, using a calorimetric method, the thermal effect and metabolic rate of a local area of living tissue. A value is computed as follows for the thermal metabolism at the local area of living tissue, or for the metabolic intensity at the local area of living tissue: applying a heatproof and waterproof applicator onto the surface of the skin with a dosed pressure, forming a closed system in the local area of tissue under the applicator; measuring the temporal dynamics of the physiological parameters of the local area of tissue under the applicator. In a monitoring mode, measuring the temporal dynamics of the climatic parameters of the surrounding environment. Then, computing a tissue enthalpy value, taking into consideration the influence of the climatic parameters. Calculating a value for the metabolic thermal effect of the local area of living tissue by means of a fundamental equation of thermodynamics linking tissue enthalpy to thermodynamic state variables. Computing relative changes in blood glucose levels, proportional to the value of the thermal metabolism at the local area of living tissue. The indicated method is carried out using a device containing a heatproof and waterproof applicator, physiological parameter sensors, climatic parameter sensors, a device for creating a calibrating effect on an area of tissue under the applicator, and a mounting platform, affixed above the applicator, for securing the climatic parameter sensors.