MARKERS AND THEIR RATIO TO DETERMINE THE RISK FOR EARLY-ONSET PREECLAMPSIA

摘要

The application discloses new biomarkers for early-onset preeclampsia based on the finding that the ratio between GBP-1 and ESM-1 in plasma samples was significantly increased in women that develop severe early-onset pre-eclampsia compared to healthy control pregnancies: the ratio between GBP-1 and ESM-1 is a prognostic parameter to identify the women at risk for severe early- onset pre-eclampsia as early as 12±2 weeks of gestation and can serve both as an important rule-in and rule-out parameter.