METHOD FOR INDUCING PLURIPOTENT STEM CELL IN THREE-DIMENSIONAL REPROGRAMMING SYSTEM USING COMBINATION OF REPROGRAMMING FACTORS

摘要

Provided is a method for inducing a pluripotent stem cell in a three-dimensional reprogramming system using a combination of reprogramming factors. The method uses a collagen frame and calcium phosphate nanoparticle as a genetic vector to construct a three-dimensional non-viral gene delivery system. The method can be used for researching pluripotency reprogramming of a human somatic cell.