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Compositions and methods for inhibiting activity of hypoxia-inducible transcription factor complex and its use for treatment of tumors
Compositions and methods for inhibiting activity of hypoxia-inducible transcription factor complex and its use for treatment of tumors
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机译:抑制低氧诱导的转录因子复合物活性的组合物和方法及其在肿瘤治疗中的用途
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摘要
Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes. An embodiment of the present invention is directed to a method for interfering with hypoxia-induced transcriptional pathway. Generally, the method according to this embodiment comprises contacting a cell with at least one compound according to either Formula I, Formula II or Formula III, or a salt, solvent or hydrate thereof.
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