PREPARATION METHODS FOR OSELTAMIVIR CARBOXYLIC ACID HYDROCHLORIDE AND ATOMIZED AGENT THEREOF

摘要

A preparation method for oseltamivir carboxylic acid hydrochloride comprises the following steps: a, introducing protective groups A to amidos of oseltamivir phosphate 1, so as to obtain a compound 2; b, hydrolyzing ester groups on the compound 2 under the action of strong alkali, so as to obtain a compound 3; and c, taking off the protective groups A of the compound 3 by means of hydrogen chloride, so as to obtain oseltamivir carboxylic acid hydrochloride 4. A reaction route is shown in formula (I). By means of the directly synthesized oseltamivir carboxylic acid hydrochloride and an atomized agent thereof, direct stimulation effects of drugs on gastrointestinal tracts can be avoided, and possible adverse reactions can be reduced by using a low dosage.