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Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
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机译:免疫调节性寡核苷酸(IRO)化合物可调节基于Toll样受体的免疫应答
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#$%^&*AU2016250372B220180405.pdf#####1001613061 Abstract of the disclosure The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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