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SHEEP-DERIVED LOW MOLECULAR WEIGHT HEPARIN, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

机译:绵羊源性低分子量肝素,其制备方法及其应用

摘要

A sheep-derived low molecular weight heparin, comprising sheep dalteparin sodium, sheep nadroparin calcium, sheep tinzaparin sodium, sheep parnaparin sodium, and sheep bemiparin sodium. The sheep-derived low molecular weight heparin has a common provenance characteristic, and in chemical structure, the content of the main disaccharide ΔUA2S-GlcNS6S(ΔIS) thereof is 66%-74%. The sheep-derived low molecular weight heparin has physical and chemical properties and biological activity similar to those of a pig-derived low molecular weight heparin, so that the source of low molecular weight heparin drugs is expanded. The method for preparing a sheep-derived low molecular weight heparin is simple and easy to implement, and the process is stable. The obtained product is refined and can meet the requirements of pharmacopoeias on the current low molecular weight heparin. The sheep-derived low molecular weight heparin also has the halal property that the pig-derived low molecular weight heparin lacks, has a huge market among Muslim groups, countries and regions, and can be applied in anticoagulant, antithrombotic, antiinflammatory, anticancer and halal drugs.
机译:绵羊来源的低分子量肝素,包括绵羊达肝素钠,绵羊萘达普林钙,绵羊替扎肝素钠,绵羊帕那肝素钠和绵羊贝米肝素钠。绵羊来源的低分子量肝素具有共同的来源特征,并且在化学结构上,其主要二糖ΔUA2S-GlcNS6S(ΔIS)的含量为66%-74%。绵羊来源的低分子量肝素具有与猪来源的低分子量肝素相似的理化性质和生物学活性,因此,低分子量肝素药物的来源得以扩展。一种羊源性低分子量肝素的制备方法简单易行,工艺稳定。所得产品经过精制,可以满足目前低分子量肝素药典的要求。绵羊来源的低分子量肝素还具有猪来源的低分子量肝素所缺乏的清真特性,在穆斯林团体,国家和地区之间具有巨大的市场,可用于抗凝,抗血栓形成,抗炎,抗癌和清真毒品。

著录项

  • 公开/公告号WO2018032502A1

    专利类型

  • 公开/公告日2018-02-22

    原文格式PDF

  • 申请/专利权人 SUZHOU RONNSI PHARMA CO. LTD.;

    申请/专利号WO2016CN96030

  • 发明设计人 JIN YONGSHENG;JIN CAIJUAN;YAO YIMING;

    申请日2016-08-19

  • 分类号C08B37/10;A61K31/727;

  • 国家 WO

  • 入库时间 2022-08-21 12:45:40

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