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Methods and compositions for identifying and treating subjects at risk for checkpoint blockade therapy associated colitis
Methods and compositions for identifying and treating subjects at risk for checkpoint blockade therapy associated colitis
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机译:鉴定和治疗有检查点封锁疗法相关结肠炎风险的受试者的方法和组合物
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摘要
The present invention relates to methods and compositions for identifying subjects treated with or considered for treatment with checkpoint blockade therapeutic agents that are at higher or lower risk for developing checkpoint therapy associated colitis, by analyzing the intestinal microbiome of those subjects. It is based, at least in part, on the discovery that the abundance of certain intestinal microbiota of the phyla Bacteroidetes, including the bacteria in the families Bacteroidaceae, Rikenellaceae, and Barnesisllaceae, and/or an increase or decrease in microbial genetic pathways involved in polyamine transport and/or B vitamin biosynthesis (e.g., (riboflavin (B2), pantothenate (B5) and thiamine (B1)) are associated with the likelihood of developing checkpoint therapy associated colitis.
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