A method for risk prediction and medication guidance of osteoporosis based on exome analysis and panel design

摘要

#$%^&*AU2018100319A420180412.pdf#####Abstract This invention provides a method for risk prediction and medication guidance of osteoporosis based on exome analysis and panel design. Firstly, we selected 43 genes related to osteoporosis or treatment of osteoporosis to design a panel. Then by using BWA, Picard-tools, GATK, and Annovar, a individual's genetic variants can be found, the steps of which includes mapping, preprocessing, variants calling, variants filtration, and annotation. Finally, a Perl program we designed can be used to select target region so that we have an insight into genetic information related to osteoporosis of the individual and help to achieve the tailored therapy. 1