Antimalarial medicine intermediates 2,4-dichlorobenzoic acid synthesis method

摘要

#$%^&*AU2018100397A420180517.pdf#####5 Abstract Antimalarial medicine intermediates 2,4-dichlorobenzoic acid synthesis method, comprises the following steps: 4-5 mol N, N-dimethylacetamide solution, 3-4 mol 5 boron trifluoride acetic acid powder were added to the reaction vessel, and the stirring speed was maintained at 90-110 rpm for 30-40 minutes, 2 mol 2,4-dichloro-6-amino-isobutylbenzene solution was added, raised the temperature of the solution to 40-50'C, kept for 100-130 min, continued to raise the temperature to 60-70 C, kept for 30-40 min, filtrated and the precipitation was washed with 10 1-chloro-2-methylpropane solution, the filtrate and the washing liquid were combined, the oxalic acid solution was added to adjust the pH to 4-5, reduced the solution temperature to 10-15 'C, precipitated the crystal, filter it and dehydrated with the dehydration, got finished product 2, 4 - dichlorobenzene formic acid.