CRYSTAL FORM OF ACP-196, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION THEREOF

摘要

A crystal form of ACP-196, a preparation method of the crystal form, a pharmaceutical composition thereof and use of the crystal form in the preparation of drugs for treatment and/or prevention of Bruton's tyrosine kinase (BTK)-mediated disorders such as autoimmune diseases or disorders, heteroimmune diseases or disorders, cancers including lymphoma and inflammatory diseases or disorders. As compared with the known solid form of ACP-196, the crystal form has advantages in crystallinity.