A combination of drugs for use in a method for the prevention or treatment of cancer metastasis in an individual with a primary cancer is provided. The combination is administered to the individual and comprises a sub-anticoagulating heparin formulation, for example a sub-anticoagulating dose of a low molecular weight heparin (LMWH) formulation, and a therapeutically effective dose of a statin. The combination significantly decreases endothelial barrier permeability while avoiding risk of bleeding by using a sub-anticoagulation heparin formulation.
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