MEANS AND METHODS FOR DETERMINING EFFICACY OF FLUOROURACIL (5-FU) IN COLORECTAL CANCER (CRC) THERAPY

摘要

The present invention relates to a method for determining the susceptibility/responsiveness of (a) cancer cell(s), preferably (a) colorectal cancer cell(s), to the treatment with fluorouracil (5-FU). Further, the present invention relates to a method of selecting (a) cancer cell(s), (a) cancer tissue(s) or (a) tumor sample(s) of colorectal cancer (CRC) with susceptibility to fluorouracil (5-FU). Furthermore, an in vitro method for the identification of a responder for or a subject, preferably a human patient, suffering from colorectal cancer (CRC) to fluorouracil (5-FU) is disclosed. The present invention also relates to a method of monitoring the efficacy of a treatment of the colorectal cancer (CRC) with fluorouracil (5-FU).