DETECTION OF TRANSIENT TROPONIN PEAKS FOR DIAGNOSIS OF SUBJECTS AT HIGH RISK OF CARDIOVASCULAR DISEASE

摘要

The present invention provides a method to assess troponin peaks in a subject to estimate CHD risk, said method comprising a) fine-temporal serial testing in body fluid samples obtained from the subject the concentration of troponin; b) assessment of troponin peaks in a subject, wherein preferably an accumulative peak score is computed, and whereby peak height and peak frequency are indicative for the risk of CHD in the subject; c) the troponin peaks are assessed and corresponding CHD risk computed in an ongoing fashion; d) a clinical algorithm is used to determine an increased CHD risk in the subject. The present invention also provides a method to use above method to select a suitable therapy against CHD for the subject, to monitor treatment effectiveness and to guide treatment course in a subject. In an alternative, the assessment of troponin peaks will be performed in combination with the assessment of NT-proBNP peaks to estimate CHD risk.