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CP-IRGD POLYPEPTIDE, IDPP NANOPARTICLE, DRUG-LOADING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
CP-IRGD POLYPEPTIDE, IDPP NANOPARTICLE, DRUG-LOADING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
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机译:CP-IRGD多肽,IDPP纳米颗粒,药物负载化合物,制备方法及其用途
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摘要
The present invention relates to the technical field of medicines and provides a CP-iRGD polypeptide, an iRGD-DOTAP-mPEG-PLA nanoparticle, a drug-loading compound, a preparation method therefor and uses thereof. In the present invention, an amphiphilic mPEG-PLA diblock copolymer is modified by using a positively charged amphiphilic substance DOTAP and a modified CP-iRGD polypeptide having a tumor targeting effect, and a self-assembling method is used to prepare the iRGD-DOTAP-mPEG-PLA nanoparticle of a degradable gene vector, i.e., the iDPP nanoparticle. The nanoparticle can introduce gene plasmids into tumor cells.
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