PROCESS FOR THE SYNTHESIS OF STIMULUS-RESPONSIVE MAGNETIC NANOPARTICLES

摘要

Process for preparing magnetic nanoparticles coated with a thermo- or Ph-responsive polymer, characterized in that it comprises the radical polymerization of a monomer or co-monomers susceptible of forming a thermo-polymer or Ph-responsive copolymer in a solution including magnetic nanoparticles functionalized at their surface with a polymerization initiator of formula (I): wherein: R₃ is hydrogen or hydroxyl, Hal is a halogen selected from bromine, chlorine and iodine, m is an integer from 1 to 10, preferably from 1 to 3, and R₁ and R₂, independently of one another, are selected from hydrogen, methyl and phenyl. The coated particles are useful, particularly as carriers of a drug in therapeutic treatments by hyperthermia and/or in situ release of the drug.