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BIOSENSOR USING DNA-BASED CONDUCTIVE NANOWIRE AND FABRICATION METHOD THEREFOR

机译:基于DNA的导电纳米生物传感器及其制备方法

摘要

The present invention relates to a biosensor using a DNA-based conductive nanowire and a fabrication method therefor and, more particularly, to a biosensor able to determine the onset of a disease at high sensitivity, using a DNA-based conductive nanowire, the biosensor comprising: a DNA-based conductive nanowire formed by coating with conductive nanoparticles which are spontaneously positively charged; and a protein detection receptor coupled with the DNA-based conductive nanowire by electrostatic attraction, and a fabrication method therefor. A biosensor using a DNA-based conductive nanowire according to the present invention is fabricated by a fabrication method comprising: a DNA alignment step (S100) of selectively aligning DNA on a substrate, a DNA-based conductive nanowire manufacturing step (S200) of coupling the aligned DNA with positively charged, conductive nanoparticles to manufacture a spontaneously, positively charged DNA-based conductive nanowire, and a protein detection receptor immobilizing step (S300) of immobilizing a receptor for detecting a protein to the DNA-based conductive nanowire.
机译:本发明涉及一种使用基于DNA的导电纳米线的生物传感器及其制造方法,更具体地,涉及一种能够使用基于DNA的导电纳米线以高灵敏度确定疾病发作的生物传感器,该生物传感器包括:通过涂覆自发带正电的导电纳米粒子形成的基于DNA的导电纳米线;通过静电吸引与基于DNA的导电纳米线偶联的蛋白质检测受体及其制备方法。通过包括以下步骤的制造方法来制造使用根据本发明的基于DNA的导电纳米线的生物传感器:DNA对准步骤(S100),其在基板上选择性地对准DNA;偶联的基于DNA的导电纳米线制造步骤(S200)。将具有带正电的导电纳米粒子的对齐的DNA制成自发的,带正电的基于DNA的导电纳米线,以及将用于检测蛋白质的受体固定到基于DNA的导电纳米线的蛋白质检测受体固定步骤(S300)。

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