NUTLIN-3α FOR CONTROLLING INTRACELLULAR MYCOBACTERIUM TUBERCULOSIS, AND COMPOSITION AND METHOD FOR REGULATING EXPRESSION OF P53

摘要

The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis including a Nutlin-3α compound as an active ingredient. A Nutlin-3α compound, which is an active ingredient according to the present invention, has an effect of inhibiting the proliferation of Mycobacterium tuberculosis by inducing the apoptosis of macrophages that have been infected with Mycobacterium tuberculosis through the overexpression of p53. Thus, a method according to the present invention including the Nutlin-3α compound as an active ingredient may be usefully used for preventing or treating tuberculosis.