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METHODS OF MAKING IMPROVED HUMAN INTESTINAL ORGANOID COMPOSITIONS VIA APPLICATION OF STRAIN AND HUMAN INTESTINAL ORGANOID COMPOSITIONS THEREOF
METHODS OF MAKING IMPROVED HUMAN INTESTINAL ORGANOID COMPOSITIONS VIA APPLICATION OF STRAIN AND HUMAN INTESTINAL ORGANOID COMPOSITIONS THEREOF
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机译:通过应用应变和人类肠道有机体成分来改善人体肠道有机体成分的方法
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摘要
Disclosed herein are methods of enhancing development of a three-dimensional in vitro model of an intestinal tissue (HIO), which may be derived from a precursor cell. The precursor cell may be, for example, an embryonic stem cell, an induced pluripotent stem cell (iPSC), or the like. The in vitro HIO model may be characterized in that the HIO has a lumen, in which a lengthening device may be inserted to promote development of the HIO. Compositions derived from the disclosed methods are also described.
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