PCSK9 Composition for increasing amount of low density lipoprotein receptor by inhibition of PCSK9 gene expression comprising Rubi fructus extract as effective component and uses thereof

摘要

The present invention relates to a composition containing a Rubus coreanus extract or a fraction thereof as an active ingredient for decreasing the PCSK9 gene expression increased by a statin-based compound or for increasing a low-density lipoprotein receptor (LDLR) decreased by the statin-based compound. The composition of the present invention can lower blood cholesterol level by improving the expression of a low-density lipoprotein receptor by means of inhibition of PCSK9 gene expression. In addition, by lowering the amount of cholesterol in blood, the composition can be utilized in prevention, alleviation or treatment of metabolic diseases such as obesity, diabetes mellitus type 2, hypertension, cardiovascular diseases and hyperlipidemia.