The present invention relates to a complex formulation of Eperisone sustained-release microspheres and Aceclofenac. More specifically, the present invention relates to a complex formulation including: Eperisone sustained-release microspheres which use one or more saccharides selected from microcrystalline cellulose, anhydrous lactose, starch, sugar, maltitol, or mannitol as a seed for the microspheres, and obtained by coating Eperisone, an acidifier, and a release-controlling polymer; and Aceclofenac. When the Eperisone sustained-release microspheres and Aceclofenac, one of a non-steroidal anti-inflammatory analgesic, are administered as a complex formulation, Eperisone maintains a certain level of solubility in the gastrointestinal tract while showing a synergistic effect with the Aceclofenac, and the concentration of Eperisone in the blood can be maintained consistently, thereby providing excellent bioavailability.
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