PSMA xCD3 Cross-species-specific PSMAxCD3 bispecific single chain antibody

摘要

The present invention is directed to a first binding domain capable of binding to an epitope of a human and non-chimpanzee primate CD3 epsilon chain, said epitope being part of an amino acid sequence belonging to the group consisting of SEQ ID NOS: 2, 4, 6 and 8; To a bispecific single chain antibody molecule comprising a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The present invention also provides nucleic acids, vectors, host cells and methods for producing the products, which encode the bispecific single chain antibody molecules. The present invention also relates to a pharmaceutical composition comprising said bispecific single chain antibody and to the medical use of said bispecific single chain antibody molecule.