The present invention relates to a microfluidic device capable of neural network analysis and drug screening of cells, comprising: a microelectrode chip including a plate provided with microelectrodes and a first polymer sheet coated on a surface of the plate such that the microelectrodes are exposed to the outside; And a chip cover coupled to an upper portion of the microelectrode chip, the second cover including a first polymer sheet and a second polymer sheet, To form a flow path through which the drug flows.According to the present invention, a chip cover for drug screening is detachably coupled to the microelectrode chip. Therefore, drug screening can be performed on the microelectrode chip by bonding the chip cover to the microelectrode chip after constructing the neural network. In this case, during cell culture, microelectrode chips can be placed in an incubator so that the developmental process of the neural network can be independently observed without being disturbed by the composition of the microfluidic device such as the cover. In addition, when the neural network is sufficiently built up on the microelectrode chip, the chip cover for drug screening can be assembled to observe the drug reaction of the cell without the noise generated during the construction of the neural network.
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