Antimicrobial peptides with high synergistic effect with antibiotics against multidrug resistant gram-negative bacteria and their uses

摘要

The present invention relates to an antibacterial peptide having an improved antibacterial activity against gram-negative multi-drug resistant bacteria, more specifically, to an antibacterial pharmaceutical composition capable of creating a synergistic effect against gram-negative multi-drug resistant bacteria by administering the antibacterial peptide in combination with an antibiotic agent; a food additive; a food additive; a feed additive; an antiseptic composition; and an antibacterial quasi-drug composition. The antibacterial peptide of the present invention exhibits significant antibacterial activity against gram-negative bacteria, and exhibits a significant synergistic effect when being co-administered with an antibiotic agent that has strong antibacterial activity against gram-positive bacteria only while having no or low antibacterial activity against gram-negative bacteria, thereby exhibiting excellent antibacterial effects on gram-positive bacteria, gram-negative bacteria, and antibiotic resistant strains thereof.