TGF-beta superfamily type I and type II receptor variant polymorphs and uses thereof

摘要

In certain aspects, the disclosure provides a heterologous chemical polypeptide complex comprising the extracellular domain of the type I serine / threonine kinase receptor of the TGF-beta family and the extracellular domain of the type I serine / threonine kinase receptor of the TGF-beta family to provide. In some embodiments, the disclosure provides a soluble polypeptide complex comprising an extracellular domain of a Type II receptor selected from ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the present disclosure provides soluble polypeptide complexes comprising extracellular domains of type I receptors selected from ALKl, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. Optionally, the soluble complex is a heterodimer. In certain aspects, such soluble polypeptide complexes can be used for the production of a tissue or cell growth comprising hematopoietic cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumor, cancer cells, and / May be used to control (promote or inhibit). In certain aspects, such soluble polypeptide complexes can be used to improve muscle formation, bone formation, hematopoiesis, improvement of metabolic parameters, and improvement of these tissues, cell networks, and endocrin systems.