Compositions for Treating Skin Wound Comprising Exosome Derived from Stem Cell Treated with Thrombin

摘要

The present invention relates to a pharmaceutical composition for preventing or treating a skin wound, comprising an exosome derived from a thrombin-treated stem cell as an effective component; a pharmaceutical formulation comprising the same; and a production method of the same. Being a cell-free agent, an exosome-based therapeutic agent of the present invention has a low risk of causing cancers, does not have the problems of transplant rejection, and does not cause microvascular obstruction when administered systematically. The agent, which is not a cell, but a material isolated from a cell, can be pharmaceutically developed into an off-the-shelf product, thereby reducing the production cost. The agent has the advantage of exhibiting outstanding angiogenesis and skin wound healing effects even at a low concentration of exosomes due to the thrombin treatment effect.