A composition for detecting circulating integrin beta-3 biomarker, and a method for evaluating the presence or progress of cancer, drug resistance of cancer, and stomach cancer

摘要

In order to detect extracellular vacuoles (EV), which are also released by CTCs, tumor stem cells, CTCs or cancer cells, extracellular vesicles (EVs) containing exosomes and microvesicles, and tumors derived from CTCs or EVs, Compositions and methods are provided that include the use of beta-3 integrin to assess drug resistance to tumor progression and, for example, breast, colon, lung and pancreatic cancer. In another embodiment, a patient fluid sample, e. G., Blood, is taken and used to detect cancer stem cells, EV- and / or CTC-containing? -3 integrin and / or? _V ? ₃ integrin. Compositions and methods using the biomarker? -3 integrin for anticancer drug design; And conjugation of an imaging agent or therapeutic agent to an antibody that targets integrin [beta] ₃ for the detection and / or targeted destruction of integrin [beta] -3 expressing cancer stem cells and / or CTC.