- Core-shell fibrous cell carriers incorporating ion-emitting bioactive glass nanoparticles and its use

摘要

The present invention relates to a core-shell fibrous cell carrier, and a preparation method of the core-shell fibrous cell carrier, wherein the core-shell fibrous cell carrier comprises: a core containing cells and collagen; and a shell containing alginate and surrounding the periphery of the core, wherein the core or shell comprises bioactive glass nanoparticles (BGn). In particular, the present invention provides a preparation method which comprises the step of injecting a core material and a shell material at a constant rate into a water bath containing calcium chloride by using needles that share the center and have different diameters from each other, wherein injected from an inner needle is a core material which contains cells and collagen, and selectively contains bioactive glass nanoparticles; and injected from an outer needle is a shell material which contains alginate, and selectively contains bioactive glass nanoparticles. In addition, the present invention provides a composition for bone or cartilage regeneration which comprises the core-shell fibrous cell carrier. The core-shell fibrous cell carrier comprising bioactive glass nanoparticles according to the present invention is in the form of a hydrogel that is easy to mold, and thus can be implanted by directly filling even a site of damaged tissue that is small or has a complicated structure, and since ions necessary for bone formation are emitted from the bioactive glass nanoparticles, thus effectively inducing bone differentiation, tissue restoration in bone deficient sites such as alveolar bone can be greatly enhanced.