- Core-shell fibrous cell carriers incorporating ion-emitting bioactive glass nanoparticles and its use

摘要

The present invention relates to a core-shell fibrous cell carrier comprising a core comprising cells and collagen, and a shell comprising alginate surrounding the core, wherein the core or shell comprises a bioactive glass (BGn) The present invention relates to a core-shell fibroblast cell transporter and a method for producing the core-shell fibroblast cell transporter, which comprises the steps of: Comprising injecting a core material comprising a living glass nanoparticle at a constant rate into a water bath containing calcium chloride from an external needle and a shell material comprising alginate and optionally bioactive glass nanoparticles and The bone or cartilage regeneration vessel containing the core-shell fibrous cell carrier It is to provide sacrament. The core-shell fibrous cell carrier containing the bioactive glass nanoparticles of the present invention is easily formed into a hydrogel form and can be directly implanted in a tissue damage area in a small or complex form, The ions necessary for formation can be released to effectively induce bone differentiation, so that the tissue regeneration ability of the bone-missing portion of the alveolar bone can be greatly improved.