Heteroform monodisperse polyethylene glycols, intermediates for the production of hetero-type monodisperse polyethylene glycols, their preparation method, and hetero-type monodisperse polyethylene glycol conjugates

摘要

The following formula (1) NH ₂ - (CH ₂ CH ₂ O) _a -CH ₂ CH ₂ COOH (1) (In the above formula (1), a represents an integer of 6 to 40) As a heterogeneous monodisperse polyethylene glycol containing a compound represented by the following formula: (A) a chromatogram detected by a differential refractometer for separating the hetero-type monodisperse polyethylene glycol using reversed phase chromatography, (B) separating the hetero-type monodisperse polyethylene glycol using cation exchange chromatography (C) a heterogeneously dispersed polyethylene glycol containing the compound represented by the formula (1) is derivatized and separated by anion exchange chromatography, And the chromatograms detected by the differential refractive index meter of the above-mentioned embodiments satisfy the respective specific relational expressions.