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Method for producing hetero-type monodisperse polyethylene glycol and intermediate for producing hetero-type monodisperse polyethylene glycol

机译:杂型单分散聚乙二醇的制备方法及杂型单分散聚乙二醇的中间体

摘要

Provided is a hetero type monodispersed polyethylene glycol which contains a compound represented by formula (1) ((1): NH 2 -(CH 2 CH 2 O) a -CH 2 CH 2 COOH (in formula (1), a is an integer between 6 and 40)) and in which the following each satisfy a specified relational expression: (A) a chromatogram detected by a differential refractometer when separation is carried out using reversed phase chromatography; (B) a chromatogram detected by a differential refractometer when separation is carried out using cation exchange chromatography; and (C) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol containing a compound represented by formula (1) is derivatized and separation is carried out using anion exchange chromatography.
机译:提供一种杂式单分散聚乙二醇,其包含由式(1)表示的化合物((1):NH 2-(CH 2 CH 2 O)a -CH 2 CH 2 COOH(在式(1)中,a为6至40之间的整数),其中以下各项均满足指定的关系表达式:(A)当使用反相色谱法进行分离时,由示差折光计检测到的色谱图; (B)当使用阳离子交换色谱法进行分离时,由示差折光仪检测的色谱图; (C)是将含有式(1)表示的化合物的杂化型单分散聚乙二醇衍生化并使用阴离子交换色谱法进行分离时利用差示折光仪检测的色谱图。

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