HYPROMELLOSE ACETATE SUCCINATE AND METHOD FOR PRODUCING HYPROMELLOSE ACETATE SUCCINATE

摘要

Provided is a producing method of hypromellose acetate succinate (HPMCAS), which can reduce an average particle diameter of an HPMCAS particle to a desired range without a grinding process. Specifically, the method comprises: an esterification process for acquiring a reacting solution which contains raw HPMCAS by reacting hypromellose with an esterification agent in the presence of a catalyst; an educing process for acquiring a suspension of HPMCAS from eduction of the raw HPMCAS by mixing the reacting solution with water; a liquid separating process for acquiring liquid-separated HPMCAS by separating a liquid from the suspension of HPMCAS with a centrifugal decanter; and a drying process for drying the liquid-separated HPMCAS.