Probes for detecting formaldehyde or measuring formaldehyde concentration two-photon ratiometric fluorescence imaging and concentration measurement of formaldehyde in cell or tissue using the sames

摘要

The present invention relates to a composition for formaldehyde detection or concentration measurement, and to two-photon rate-based fluorescence imaging and concentration quantification of formaldehyde in a cell or tissue using the composition. The composition for formaldehyde detection or concentration measurement according to the present invention can implement rate-based fluorescence imaging of formaldehyde under a two-photon excitation condition using light in a near-infrared region, and detect and measure the concentration of formaldehyde in a cell or organ tissue. Therefore, the composition can be useful for detecting and measuring the concentration of endogenous formaldehyde, for identifying the biological role of in vivo formaldehyde, and particularly for detecting or measuring the concentration of formaldehyde in deeply located tissue (crypts in the colon or villus or crypts in the small intestine).