A pharmaceutical composition containing a camptothecin analog derivative

摘要

Disclosed is a medicinal preparation containing a macromolecular camptothecin derivative in which a camptothecin derivative having nanoparticle-forming properties in association with an aqueous solution is bonded to a polymer carrier. do. It is an object of the present invention to provide a medicinal preparation having nanoparticle formation, camptothecin derivative binding stability, and storage stability, which are particularly important factors. The present invention also relates to a pharmaceutical preparation containing a block copolymer and a saccharide to which a polyglutamic acid segment containing a glutamic acid unit linked with a polyethylene glycol segment and a camptothecin derivative is linked, wherein the pharmaceutical preparation comprises a complex in an aqueous solution, The medicinal preparation is preserved at 40 占 폚 for 4 weeks under light shielding, and the rate of change of the scattered light intensity of the above-mentioned medicament preparation is 20% or less.