Injectable botulinum toxin preparations and methods using these with long-lasting therapeutic or cosmetic effects

摘要

The present invention provides novel injectable compositions comprising a bournei toxin that can be administered to a subject for a variety of therapeutic, aesthetic, and / or cosmetic purposes. The injectable composition as embodied by the present invention may be used in combination with other botulinum toxin formulations as compared to conventional botulinum toxin formulations, reduced antigenicity, reduced tendency to undergo undesirable localized spread after injection, increased duration of clinical efficacy, Lt; RTI ID = 0.0 and / or / RTI improved stability. According to the present invention, a single treatment of a composition by injection provided by the described treatment methods provides a significant clinical response in the subject being treated and a duration of at least a six-month effect.