RECOMBINED ESCHERICHIA COLI STRAIN WITH IMPROVED SUCCINIC ACID PRODUCTION INCLUDING OVEREXPRESSED CA AND ppc AND INACTIVATED pykF AND pykA, AND MANUFACTURING METHOD THEREOF

摘要

The present invention relates to recombined escherichia coli strain with improved succinic acid production, and a manufacturing method thereof. The recombined escherichia coli strain includes an expression vector which includes a nucleic acid sequence for coding carbonic anhydrase, and a nucleic acid sequence for coding phosphoenolpyruvate carboxylase; and inactivates a pyruvate phosphorylase F gene and a pyruvate phosphorylase A gene. The present invention can be effectively used in succinic acid production from carbon dioxide by highly increasing the succinic acid production using the carbon dioxide compared to conventional strain.;COPYRIGHT KIPO 2018