DNA Method for integrated analysis of DNA excision repair products checkpoint signaling and apoptosis in human cells

摘要

The present invention relates to a simultaneous detection method for DNA fragments and apoptosis generated during a DNA repair phase. More specifically, the simultaneous detection method has the effects of quantitatively detecting biotin-labeled DNA fragments and detecting cellular responses to DNA damage and the following signaling and apoptosis, at the same time. Further, unlike the conventional detection method using radioactive isotopes, the simultaneous detection method of the present invention is not limited to the use of an antibody specific to a particular damage, but can be utilized in a broad range and can enable a quantitative analysis with higher sensitivity.