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Medicinal preparations containing camptothecin analog macromolecule derivatives
Medicinal preparations containing camptothecin analog macromolecule derivatives
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机译:含有喜树碱类似物大分子衍生物的药物制剂
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摘要
The present invention relates to a pharmaceutical preparation containing a macromolecular camptothecin derivative in which a camptothecin derivative having nanoparticle-forming properties in association with an aqueous solution is bound to a polymer carrier, and to provide a pharmaceutical preparation composition with improved safety stability . It is an object of the present invention to provide a medicinal preparation having excellent preservation stability in terms of the formation of associative aggregates and chemical stability, which are particularly important factors. The present invention relates to a pharmaceutical preparation containing a block copolymer to which a polyglutamic acid segment containing a glutamic acid unit linked with a polyethylene glycol segment and a camptothecin derivative is linked and at least one additive selected from the group consisting of arginine, histidine and sodium chloride Or a pharmaceutically acceptable salt thereof.
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