VLRB C4bp Fusion protein comprising human C4bp oligomerization domain linked to hagfish VLRB protein with deleted hydrophobic tail domain and uses thereof

摘要

The present invention relates to a recombinant expression vector including a polynucleotide encoding a human-derived C4b-binding protein (C4bp) oligomerized domain linked to 3′-terminal end of a gene encoding a hydrophobic tail domain-removed hagfish-derived variable lymphocyte receptor B (VLRB) protein. The present invention further relates to a host cell transformed by the recombinant expression vector, a fusion protein in which the human-derived C4bp oligomerized domain is linked to the hydrophobic tail domain-removed hagfish-derived VLRB protein, and use thereof and which is produced by the host cell, and a polyvalent antibody which ensures increased binding ability to target antigens and is composed of polymers by self-assembly of the fusion protein. According to the present invention, the hagfish-derived fusion antibody can be useful in the field of biomarker development and diagnosis.