VLRB C4bp Fusion protein comprising human C4bp oligomerization domain linked to hagfish VLRB protein with deleted hydrophobic tail domain and uses thereof

摘要

The present invention includes a polynucleotide encoding a human-derived C4b-binding protein oligomerization domain linked to the 3 ' -terminal of a gene encoding a wild-type VLRB (variable lymphocyte receptor B) protein from which a hydrophobic tail domain has been removed A recombinant expression vector, a host cell transformed with the recombinant expression vector, a fusion protein in which the humanized C4bp oligomerization domain is linked to the VLRB protein derived from the horseshoe, from which the hydrophobic tail domain has been removed, produced by the host cell, The present invention relates to a polyvalent antibody having increased binding ability to a target antigen. The fusion antibody derived from a falconer of the present invention can be usefully used for the development and diagnosis of a biomarker.