REGIMENS FOR INTRA-ARTICULAR VISCOSUPPLEMENTATION

摘要

The present invention provides a joint-replacement therapy for treating osteoarthritis and joint damage using an HA-based joint replacement therapy, particularly a joint replacement solution having a short-term intra-articular retention time of less than 3 weeks. The joint fluid replenisher used in the method of the present invention is further characterized by containing less than 20 mg / ml of HA and more than 5% (w / w) of such HA is in gel form, for example, In an exemplary embodiment, a high-dose G-F 20 (Synvisc®) is administered in a single intra-articular knee injection of 6 ± 2 ml.