miR-30a miR-30a miR-30a as a marker for diagnosing of anti-cancer drug resistance and composition for overcoming anti-cancer drug resistance comprising it's inhibitor

摘要

The present invention relates to a pharmaceutical composition for immunity suppression for cancer drug containing an inhibitor of miR-30a and miR-30a as an anticancer agent resistance diagnostic marker as an active ingredient, specifically an increase in the expression of miR-30a in chemotherapy-resistant cancer cells in the by containing the method for using it provides the necessary information for a cancer drug resistance diagnosis of cancer patients and an inhibitor of miR-30a as an active ingredient inhibiting the expression of miR-30a or interfere with the binding of miR-30a and miR-217 cancer about it relates to a pharmaceutical composition showing the effect of suppressing the resistance. May provide information about whether resistance, according to the invention through a method of measuring the expression level of miR-30a in chemotherapy for cancer patients effectively, the pharmaceutical compositions according to the present invention, which contains an inhibitor of miR-30a If it is possible to effectively suppress resistance to the use of these anticancer agents. It may also search for cancer drug resistance inhibitors through a method for screening a substance capable of inhibiting the expression of miR-30a effectively.;