- - NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY

摘要

The present invention provides an aqueous tumor-targeted liposomal nanoparticle composition comprising an aqueous dispersion of liposomal nanoparticles. Preferably, the nanoparticles encapsulate an anti-cancer chemotherapeutic agent that can be added to the pre-formed liposome composition or incorporated into the liposome upon formation of the liposome. Liposomal nanoparticles contain regime-targeting lipids in the form of liposomes dispersed in an aqueous carrier in admixture with one or more micelles or vesicle-forming lipid materials. Preferred tumor-targeted liposomal nanoparticle compositions comprise (a) a regimen-targeting lipid component; (b) zwitterionic lipid components; (c) an amino-substituted lipid component; (d) a neutral lipid component; And (e) a polyethylene glycol-conjugated lipid component. The regumain-targeting lipid component comprises a hydrophobic lipid moiety attached by a covalent bond to a regmain-binding moiety.