首页> 外国专利> Composition for preventing or treating pulmonary fibrosis comprising exosomes extracted from adipose-derived stem cells

Composition for preventing or treating pulmonary fibrosis comprising exosomes extracted from adipose-derived stem cells

机译:用于预防或治疗肺纤维化的组合物,其包含从脂肪干细胞提取的外来体

摘要

The present invention relates to a composition for preventing or treating pulmonary fibrosis comprising exosome extracted from adipose derived stem cells as an active ingredient. The exosome extracted from adipose stem cells according to the present invention contains growth factors such as HGF (hepatocyte growth factor) and IL-10 involved in the treatment of pulmonary fibrosis and significantly reduces the fibrosis area in an animal model for inducing pulmonary fibrosis And thus may be useful for preventing or treating pulmonary fibrosis. In addition, the treatment of pulmonary fibrosis using the exosome according to the present invention is less susceptible to side effects caused by steroid drugs and antioxidants used in the treatment of pulmonary fibrosis, and can be administered by an injection method, Naturally, it can deliver exosomes to the lungs, so it can treat lung fibrosis easily and economically.
机译:本发明涉及用于预防或治疗肺纤维化的组合物,其包含从脂肪来源的干细胞提取的外来体作为活性成分。从本发明的脂肪干细胞提取的外泌体含有参与治疗肺纤维化的生长因子,例如HGF(肝细胞生长因子)和IL-10,并显着减少了用于诱导肺纤维化的动物模型中的纤维化面积,因此可能对预防或治疗肺纤维化有用。另外,使用本发明的外来体治疗肺纤维化对由治疗肺纤维化使用的类固醇药物和抗氧化剂引起的副作用较不敏感,并且可以通过注射方法给药,自然地,它可以递送外泌体进入肺部,因此可以轻松经济地治疗肺纤维化。

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