Deacetylation hydrolase of hyaluronic acid and hyaluronic acid and its derivative deacetylated by the same

摘要

The present invention relates to deacetylated hyaluronic acid hydrolase, and thus the de-acetylated hyaluronic acid and derivatives thereof by. De-acetylated hyaluronic acid and derivatives thereof according to the present invention delays an initial degradation rate in vivo, and minimizes the molecular weight and viscosity decrease of the gelation point is gelled lower than the gelling point of the hyaluronic acid is not Chemistry deacetylation It is promoted, but the survival rate of hMSC little effect on the concentrations of deacetylated hyaluronic acid and derivatives thereof in the medium. Thus, de-acetylated hyaluronic acid and derivatives thereof according to the present invention may be useful as a biomaterial of the cell, the genes, such as drug delivery systems or the like for tissue engineering of the support.;